Association of deficits in prepotent response inhibition with attention deficit and impulsive behavior among children with attention deficit hyperactivity disorder / 预防医学

Objective@#To investigate the associations of deficits in prepotent response inhibition with attention deficit and impulsive behavior in children with attention deficit hyperactivity disorder (ADHD), so as to provide insights into response inhibition training in ADHD to relieve clinical symptoms. @*Methods@# From March to December 2022, 57 children with ADHD were selected from the clinical psychology department of a tertiary hospital in Hangzhou City as the ADHD group, and 55 normal children matched by age and gender were selected from a primary school as the control group. Prepotent response inhibition, attention deficit and impulsive behavior were assessed by inhibition conflict task, visual continuous performance test (CPT) and matching familiar figures test (MFFT), respectively. The associations of deficits in prepotent response inhibition with attention deficit and impulsive behavior were analyzed using multiple linear regression model, and the predictive value of deficits in prepotent response inhibition on ADHD was evaluated using receiver operating characteristic (ROC) curve.@*Results@# The children included in the ADHD group had a mean age of (8.77±1.60) years and 44 males (77.19%), and the children included in the control group had a mean age of (9.20±1.77) years and 42 males (76.36%). The error rate of inhibition conflict task, missing report rate of visual CPT and the number of MFFT errors were higher in the ADHD group than in the control group [22.50% (12.50%) vs. 8.75% (7.00%), 24.00% (30.00%) vs. 7.50% (7.00%), 8.67±3.32 vs. 4.47±3.16; all P<0.05]. Multiple linear regression model showed that the error rate of inhibition conflict task was positively associated with the missing report rate of visual CPT (R2=0.135, β=0.091, P<0.001) and the number of MFFT errors (R2=0.092, β=0.009, P<0.001). The area under the ROC curve was 0.891, the sensitivity was 93.00%, the specificity was 80.00%, and the cut-off was 13.13%.@* Conclusions @#The deficits in prepotent response inhibition are positively associated with attention deficit and impulsive behavior.

Relationship between inhibition of ongoing responses with attention deficit and behavior disorder / 中国学校卫生

Objective@#To examine the relationship between inhibition of ongoing responses deficit with attention deficit and behavior disorder among ADHD children.@*Methods@#Totally 43 children with attention deficit hyperac tivity disorder (ADHD) aged 6-14 years who met the DSM-V criteria for ADHD were recruited. And 38 health children were recruited as the control group. Vision Continuous Performance Task (CPT) and Matching Familiar Figures Test were used to assess attention deficit and behavior disorder feature of the ADHD children. Stop-signal paradigm was used to assess the inhibition of ongoing responses.@*Results@#In the stop-signal paradigm, the ADHD children’s error rate was significantly higher than typically developing children(t=4.34, P<0.01). The ADHD children error rate in the stopsignal task was positively correlated with the wrong number miss rate in CPT task(r=0.45, P<0.01), similar finding was observed in regression analysis,with inhibition of ongoing responses accounted for 20.1% of attention deficit(t=3.21,P<0.01). In ROC curve analysis, the cut-off sore was 15.50 in the task. The error rate in stop-signal task showed no association with miss rate in Matching Familiar Figures Test(r=0.09,P>0.05).@*Conclusion@#Inhibition of ongoing responses among ADHD children is associated with attention deficit, but not with existence of behavior disorder.